Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone
Identifieur interne : 002141 ( Main/Exploration ); précédent : 002140; suivant : 002142Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone
Auteurs : Czar Louie Gaston ; Robert J. Grimer ; Michael Parry ; Silvia Stacchiotti [Italie] ; Angelo Paolo Dei Tos [Italie] ; Hans Gelderblom [Pays-Bas] ; Stefano Ferrari [Italie] ; Giacomo G. Baldi [Italie] ; Robin L. Jones [États-Unis, Royaume-Uni] ; Sant Chawla [États-Unis] ; Paolo Casali [Italie] ; Axel Lecesne [France] ; Jean-Yves Blay [France] ; Sander P. D. Dijkstra [Pays-Bas] ; David M. Thomas [Australie] ; Piotr Rutkowski [Pologne]Source :
- Clinical Sarcoma Research [ 2045-3329 ] ; 2016.
Abstract
Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosumab has also been used pre-operatively to downstage tumours with large soft tissue extension to allow for less morbid surgery. The role of Denosumab for conventional limb GCT of bone is yet to be defined. Further studies are required to determine whether local recurrence rates will be decreased with the adjuvant use of Denosumab along with surgery. The long term use and toxicity of this agent is unknown as is the proportion of patients with primary or secondary resistance. It is advised that complicated cases of GCT requiring Denosumab treatment should be referred and followed up at expert centres. Collaborative studies involving further clinical trials and rigorous data collection are strongly recommended to identify the optimum use of this drug.
Url:
DOI: 10.1186/s13569-016-0056-0
PubMed: 27651889
PubMed Central: 5022265
Affiliations:
- Australie, France, Italie, Pays-Bas, Pologne, Royaume-Uni, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Californie, Grand Londres, Hollande-Méridionale, Lombardie, Nouvelle-Galles du Sud, Rhône-Alpes, Washington (État)
- Leyde, Londres, Lyon, Milan, Sydney
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone</title><author><name sortKey="Gaston, Czar Louie" sort="Gaston, Czar Louie" uniqKey="Gaston C" first="Czar Louie" last="Gaston">Czar Louie Gaston</name><affiliation><nlm:aff id="Aff1">Oncology Service, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Birmingham, B31 2AP UK</nlm:aff><wicri:noCountry code="subfield">B31 2AP UK</wicri:noCountry></affiliation></author><author><name sortKey="Grimer, Robert J" sort="Grimer, Robert J" uniqKey="Grimer R" first="Robert J." last="Grimer">Robert J. Grimer</name><affiliation><nlm:aff id="Aff1">Oncology Service, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Birmingham, B31 2AP UK</nlm:aff><wicri:noCountry code="subfield">B31 2AP UK</wicri:noCountry></affiliation></author><author><name sortKey="Parry, Michael" sort="Parry, Michael" uniqKey="Parry M" first="Michael" last="Parry">Michael Parry</name><affiliation><nlm:aff id="Aff1">Oncology Service, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Birmingham, B31 2AP UK</nlm:aff><wicri:noCountry code="subfield">B31 2AP UK</wicri:noCountry></affiliation></author><author><name sortKey="Stacchiotti, Silvia" sort="Stacchiotti, Silvia" uniqKey="Stacchiotti S" first="Silvia" last="Stacchiotti">Silvia Stacchiotti</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Dei Tos, Angelo Paolo" sort="Dei Tos, Angelo Paolo" uniqKey="Dei Tos A" first="Angelo Paolo" last="Dei Tos">Angelo Paolo Dei Tos</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Anatomic Pathology, General Hospital of Treviso, Treviso, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anatomic Pathology, General Hospital of Treviso, Treviso</wicri:regionArea><wicri:noRegion>Treviso</wicri:noRegion></affiliation></author><author><name sortKey="Gelderblom, Hans" sort="Gelderblom, Hans" uniqKey="Gelderblom H" first="Hans" last="Gelderblom">Hans Gelderblom</name><affiliation wicri:level="3"><nlm:aff id="Aff4">Leiden University Medical Center, Leiden, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ferrari, Stefano" sort="Ferrari, Stefano" uniqKey="Ferrari S" first="Stefano" last="Ferrari">Stefano Ferrari</name><affiliation wicri:level="1"><nlm:aff id="Aff5">Department of Oncology, Rizzoli Institute, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, Rizzoli Institute, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Baldi, Giacomo G" sort="Baldi, Giacomo G" uniqKey="Baldi G" first="Giacomo G." last="Baldi">Giacomo G. 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Grimer</name><affiliation><nlm:aff id="Aff1">Oncology Service, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Birmingham, B31 2AP UK</nlm:aff><wicri:noCountry code="subfield">B31 2AP UK</wicri:noCountry></affiliation></author><author><name sortKey="Parry, Michael" sort="Parry, Michael" uniqKey="Parry M" first="Michael" last="Parry">Michael Parry</name><affiliation><nlm:aff id="Aff1">Oncology Service, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Birmingham, B31 2AP UK</nlm:aff><wicri:noCountry code="subfield">B31 2AP UK</wicri:noCountry></affiliation></author><author><name sortKey="Stacchiotti, Silvia" sort="Stacchiotti, Silvia" uniqKey="Stacchiotti S" first="Silvia" last="Stacchiotti">Silvia Stacchiotti</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Dei Tos, Angelo Paolo" sort="Dei Tos, Angelo Paolo" uniqKey="Dei Tos A" first="Angelo Paolo" last="Dei Tos">Angelo Paolo Dei Tos</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Anatomic Pathology, General Hospital of Treviso, Treviso, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anatomic Pathology, General Hospital of Treviso, Treviso</wicri:regionArea><wicri:noRegion>Treviso</wicri:noRegion></affiliation></author><author><name sortKey="Gelderblom, Hans" sort="Gelderblom, Hans" uniqKey="Gelderblom H" first="Hans" last="Gelderblom">Hans Gelderblom</name><affiliation wicri:level="3"><nlm:aff id="Aff4">Leiden University Medical Center, Leiden, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ferrari, Stefano" sort="Ferrari, Stefano" uniqKey="Ferrari S" first="Stefano" last="Ferrari">Stefano Ferrari</name><affiliation wicri:level="1"><nlm:aff id="Aff5">Department of Oncology, Rizzoli Institute, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, Rizzoli Institute, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Baldi, Giacomo G" sort="Baldi, Giacomo G" uniqKey="Baldi G" first="Giacomo G." last="Baldi">Giacomo G. Baldi</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Cancer Medicine, S. Stefano Civil Hospital, Prato, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cancer Medicine, S. Stefano Civil Hospital, Prato</wicri:regionArea><wicri:noRegion>Prato</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Robin L" sort="Jones, Robin L" uniqKey="Jones R" first="Robin L." last="Jones">Robin L. Jones</name><affiliation wicri:level="2"><nlm:aff id="Aff7">University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>University of Washington/Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff8">Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chawla, Sant" sort="Chawla, Sant" uniqKey="Chawla S" first="Sant" last="Chawla">Sant Chawla</name><affiliation wicri:level="2"><nlm:aff id="Aff9">Sarcoma Oncology Center, Santa Monica, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Sarcoma Oncology Center, Santa Monica</wicri:cityArea></affiliation></author><author><name sortKey="Casali, Paolo" sort="Casali, Paolo" uniqKey="Casali P" first="Paolo" last="Casali">Paolo Casali</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Lecesne, Axel" sort="Lecesne, Axel" uniqKey="Lecesne A" first="Axel" last="Lecesne">Axel Lecesne</name><affiliation wicri:level="1"><nlm:aff id="Aff10">Institut Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Blay, Jean Yves" sort="Blay, Jean Yves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name><affiliation wicri:level="3"><nlm:aff id="Aff11">Centre Leon Berard, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Leon Berard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Dijkstra, Sander P D" sort="Dijkstra, Sander P D" uniqKey="Dijkstra S" first="Sander P. D." last="Dijkstra">Sander P. D. Dijkstra</name><affiliation wicri:level="3"><nlm:aff id="Aff4">Leiden University Medical Center, Leiden, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Thomas, David M" sort="Thomas, David M" uniqKey="Thomas D" first="David M." last="Thomas">David M. Thomas</name><affiliation wicri:level="3"><nlm:aff id="Aff12">Garvan Institute of Medical Research, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Garvan Institute of Medical Research, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name><affiliation wicri:level="1"><nlm:aff id="Aff13">Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Center and Institute of Oncology, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Center and Institute of Oncology, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinical Sarcoma Research</title><idno type="eISSN">2045-3329</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosumab has also been used pre-operatively to downstage tumours with large soft tissue extension to allow for less morbid surgery. The role of Denosumab for conventional limb GCT of bone is yet to be defined. Further studies are required to determine whether local recurrence rates will be decreased with the adjuvant use of Denosumab along with surgery. The long term use and toxicity of this agent is unknown as is the proportion of patients with primary or secondary resistance. It is advised that complicated cases of GCT requiring Denosumab treatment should be referred and followed up at expert centres. Collaborative studies involving further clinical trials and rigorous data collection are strongly recommended to identify the optimum use of this drug.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Behjati, S" uniqKey="Behjati S">S Behjati</name></author><author><name sortKey="Tarpey, Ps" uniqKey="Tarpey P">PS Tarpey</name></author><author><name sortKey="Presneau, N" uniqKey="Presneau N">N Presneau</name></author><author><name sortKey="Scheipl, S" uniqKey="Scheipl S">S Scheipl</name></author><author><name sortKey="Pillay, N" uniqKey="Pillay N">N Pillay</name></author><author><name sortKey="Van Loo, P" uniqKey="Van Loo P">P Van Loo</name></author><author><name sortKey="Wedge, Dc" uniqKey="Wedge D">DC Wedge</name></author><author><name sortKey="Cooke, Sl" uniqKey="Cooke S">SL Cooke</name></author><author><name sortKey="Gundem, G" uniqKey="Gundem G">G Gundem</name></author><author><name sortKey="Davies, H" uniqKey="Davies H">H 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uniqKey="Yoneda T">T Yoneda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aponte Tinao, La" uniqKey="Aponte Tinao L">LA Aponte-Tinao</name></author><author><name sortKey="Piuzzi, Ns" uniqKey="Piuzzi N">NS Piuzzi</name></author><author><name sortKey="Roitman, P" uniqKey="Roitman P">P Roitman</name></author><author><name sortKey="Farfalli, Gl" uniqKey="Farfalli G">GL Farfalli</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Californie</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Lombardie</li><li>Nouvelle-Galles du Sud</li><li>Rhône-Alpes</li><li>Washington (État)</li></region><settlement><li>Leyde</li><li>Londres</li><li>Lyon</li><li>Milan</li><li>Sydney</li></settlement></list><tree><noCountry><name sortKey="Gaston, Czar Louie" sort="Gaston, Czar Louie" uniqKey="Gaston C" first="Czar Louie" last="Gaston">Czar Louie Gaston</name><name sortKey="Grimer, Robert J" sort="Grimer, Robert J" uniqKey="Grimer R" first="Robert J." last="Grimer">Robert J. Grimer</name><name sortKey="Parry, Michael" sort="Parry, Michael" uniqKey="Parry M" first="Michael" last="Parry">Michael Parry</name></noCountry><country name="Italie"><region name="Lombardie"><name sortKey="Stacchiotti, Silvia" sort="Stacchiotti, Silvia" uniqKey="Stacchiotti S" first="Silvia" last="Stacchiotti">Silvia Stacchiotti</name></region><name sortKey="Baldi, Giacomo G" sort="Baldi, Giacomo G" uniqKey="Baldi G" first="Giacomo G." last="Baldi">Giacomo G. Baldi</name><name sortKey="Casali, Paolo" sort="Casali, Paolo" uniqKey="Casali P" first="Paolo" last="Casali">Paolo Casali</name><name sortKey="Dei Tos, Angelo Paolo" sort="Dei Tos, Angelo Paolo" uniqKey="Dei Tos A" first="Angelo Paolo" last="Dei Tos">Angelo Paolo Dei Tos</name><name sortKey="Ferrari, Stefano" sort="Ferrari, Stefano" uniqKey="Ferrari S" first="Stefano" last="Ferrari">Stefano Ferrari</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Gelderblom, Hans" sort="Gelderblom, Hans" uniqKey="Gelderblom H" first="Hans" last="Gelderblom">Hans Gelderblom</name></region><name sortKey="Dijkstra, Sander P D" sort="Dijkstra, Sander P D" uniqKey="Dijkstra S" first="Sander P. D." last="Dijkstra">Sander P. D. Dijkstra</name></country><country name="États-Unis"><region name="Washington (État)"><name sortKey="Jones, Robin L" sort="Jones, Robin L" uniqKey="Jones R" first="Robin L." last="Jones">Robin L. Jones</name></region><name sortKey="Chawla, Sant" sort="Chawla, Sant" uniqKey="Chawla S" first="Sant" last="Chawla">Sant Chawla</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Jones, Robin L" sort="Jones, Robin L" uniqKey="Jones R" first="Robin L." last="Jones">Robin L. Jones</name></region></country><country name="France"><noRegion><name sortKey="Lecesne, Axel" sort="Lecesne, Axel" uniqKey="Lecesne A" first="Axel" last="Lecesne">Axel Lecesne</name></noRegion><name sortKey="Blay, Jean Yves" sort="Blay, Jean Yves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Thomas, David M" sort="Thomas, David M" uniqKey="Thomas D" first="David M." last="Thomas">David M. Thomas</name></region></country><country name="Pologne"><noRegion><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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